Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 20551110.
- Also identified by DOI 10.3899/jrheum.091455.
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Abstract
To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA). Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements. A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status. The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
Medical subject headings
- Arthritis, Rheumatoid
- Peptides, Cyclic
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-6