How can free radicals cause damage to hepatic cells. A multidisciplinary approach.

Abstract

Excessive alcohol intake is a factor in a significant percentage of all deaths. Hepatoprotective drugs aim to prevent alcoholic liver damage. Our experiments with antioxidant free radical scavengers also proved that such chemicals are hepatoprotectives. Free radical reactions play a significant role in many biological phenomena such as aging and toxic liver cell damage. Different disciplines support theories to interpret their effects. In this paper, theories are summarized as a multidisciplinary approach which can provide further explanation and challenge further investigation on alcoholic liver damage and hepatoprotection.