Killing the killer: natural killer cells to treat Ewing's sarcoma.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20554750.
- Also identified by DOI 10.1158/1078-0432.CCR-10-1368 and PMC identifier 5659354.
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Abstract
Cho and coworkers show that Ewing's sarcoma cells are highly sensitive to expanded allogeneic natural killer (NK) cells, partially through a NKG2D- and DNAM-1-dependent mechanism. Using an orthotopic murine model, they also show that irradiation significantly enhances the NK-cell killing of these tumors.
Medical subject headings
- Bone Neoplasms
- Immunotherapy
- Killer Cells, Natural
- Sarcoma, Ewing