Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20572008.
- Also identified by DOI 10.1002/jbmr.154 and PMC identifier 3153347.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis.
Medical subject headings
- CD11b Antigen
- Myeloid Cells
- Neoplasm Metastasis
- Receptors, Chemokine