NF1 inactivation revs up Ras in adult acute myelogenous leukemia.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20587590.
- Also identified by DOI 10.1158/1078-0432.CCR-10-1438.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mutations in the Ras pathway are common in myeloid malignancies. NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes cells to inhibition of mammalian target of rapamycin (mTOR), a downstream effector of Ras activation, highlighting a potential therapeutic opportunity for some AML patients.
Medical subject headings
- Gene Expression Regulation, Neoplastic
- Genes, Neurofibromatosis 1
- Leukemia, Myeloid, Acute
- Signal Transduction
- ras Proteins