Insights into schizophrenia using positron emission tomography: building the evidence and refining the focus.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20592424.
- Also identified by DOI 10.1192/bjp.bp.109.073882.
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Abstract
Schizophrenia involves dysregulation in dopaminergic transmission. Studies show heightened presynaptic striatal dopaminergic function and elevated striatal D(2)/D(3) receptor density in the brain. Cognitive impairments result from hypostimulation of D(1) receptors and are associated with dysfunction in the prefrontal cortex. Here we discuss relevant positron emissions tomography (PET) studies and provide future directions.
Medical subject headings
- Schizophrenia