Flipping MLL1's switch one proline at a time.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20602992.
- Also identified by DOI 10.1016/j.cell.2010.06.013.
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Abstract
The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.