D'oh! genes and environment cause Crohn's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20602995.
- Also identified by DOI 10.1016/j.cell.2010.06.015 and PMC identifier 4459541.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases by identifying genes that predispose individuals to these disorders. Cadwell et al. (2010) now demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility gene collude to cause inflammatory disease in the mouse gut.