Metabolic networks of longevity.

Houtkooper, Riekelt H; Williams, Robert W; Auwerx, Johan · Cell · 2010

review · Level V

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Abstract

Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.

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