Keeping p53 in check: a high-stakes balancing act.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20603009.
- Also identified by DOI 10.1016/j.cell.2010.06.026 and PMC identifier 3922053.
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Abstract
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. (2010) now use single-cell microscopy to demonstrate that alternative posttranslational modifications allow the tumor suppressor p53 to differentiate between benign breaks in DNA during the cell cycle and deleterious damage caused by mutagens.