RAF translocations expand cancer targets.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20613748.
- Also identified by DOI 10.1038/nm0710-749 and PMC identifier 4263025.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chromosomal translocations can promote cancers by eliciting the expression of fusion genes with oncogenic activity. The identification of translocations affecting <i>RAF</i> genes in prostate and gastric cancers and melanoma provides compelling evidence for the key role of RAF signaling in a subset of these cancers and suggests possible new avenues for personalized cancer therapy.
Medical subject headings
- Neoplasms
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-raf
- Translocation, Genetic