MTERF1 gives mtDNA an unusual twist.
basic_science · Level V
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- Record sourced from PubMed, PMID 20620988.
- Also identified by DOI 10.1016/j.cmet.2010.06.006.
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Abstract
Expression of mtDNA is critical for biogenesis of the oxidative phosphorylation system, but the regulatory processes are poorly understood. Recent work in Cell (Yakubovskaya et al., 2010) reports a novel DNA-binding fold in mitochondrial transcription termination factor 1 (MTERF1), which causes unwinding and base eversion at its target mtDNA sequence.