Steroids make you bigger? Fat chance says Myc.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20620990.
- Also identified by DOI 10.1016/j.cmet.2010.06.003.
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Abstract
In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a mechanism for such coordination.