Keeping them quiet: BMPs maintain adult neural stem cell quiescence.
basic_science · Level V
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- Record sourced from PubMed, PMID 20621042.
- Also identified by DOI 10.1016/j.stem.2010.06.006.
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Abstract
Neural stem cells (NSCs) in the adult dentate gyrus divide relatively infrequently, a trait that may prevent premature NSC depletion. In this issue of Cell Stem Cell, Mira et al. (2010) demonstrate that BMP signaling regulates the quiescence of dentate gyrus NSCs, restraining their proliferation to maintain long-term adult neurogenesis.