MicroRNAs as regulators of differentiation and cell fate decisions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20621048.
- Also identified by DOI 10.1016/j.stem.2010.06.012.
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Abstract
Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.
Medical subject headings
- Cell Differentiation
- Cell Lineage
- MicroRNAs