Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 20621347.
- Also identified by DOI 10.1016/j.jaci.2010.05.013 and PMC identifier 2917474.
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Abstract
IL-1 receptor-associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood. We sought to evaluate T-cell function in IRAK-4 deficient patients. We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-gamma after stimulation of PBMCs from 4 IRAK-4-deficient patients and healthy control subjects with anti-CD3 and anti-CD28. Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-gamma, but not IL-2, was significantly reduced in IRAK-4-deficient patients. IRAK-4-deficient patients have defects in T-cell activation.
Medical subject headings
- Genetic Diseases, Inborn
- Immunologic Deficiency Syndromes
- Interleukin-1 Receptor-Associated Kinases
- Lymphocyte Activation
- Receptors, Antigen, T-Cell
- T-Lymphocytes