JAK/STAT signaling in renal diseases.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20631733.
- Also identified by DOI 10.1038/ki.2010.158.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.
Medical subject headings
- Diabetic Nephropathies
- Janus Kinases
- Kidney Diseases
- Signal Transduction
- Ureteral Obstruction