Resolved: EMT produces fibroblasts in the kidney.
Where this comes from
- Record sourced from PubMed, PMID 20651165.
- Also identified by DOI 10.1681/ASN.2010060616.
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Abstract
Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.
Medical subject headings
- Cell Differentiation
- Epithelial Cells
- Fibroblasts
- Kidney
- Mesoderm