Targeting the dynamic HSP90 complex in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20651736.
- Also identified by DOI 10.1038/nrc2887 and PMC identifier 6778733.
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Abstract
The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to facilitate the function of numerous oncoproteins, and it can be argued that cancer cells are 'addicted' to HSP90. However, although recent reports of the early clinical efficacy of HSP90 inhibitors are encouraging, the optimal use of HSP90-targeted therapeutics will depend on understanding the complexity of HSP90 regulation and the degree to which HSP90 participates in both neoplastic and normal cellular physiology.
Medical subject headings
- HSP90 Heat-Shock Proteins
- Neoplasms