Giving Alzheimer's the old one-two.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20655461.
- Also identified by DOI 10.1016/j.cell.2010.07.006.
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Abstract
A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid beta-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor beta, a potential new therapeutic target for AD.