SRD5A3: A surprising role in glycosylation.
basic_science · Level V
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- Record sourced from PubMed, PMID 20655462.
- Also identified by DOI 10.1016/j.cell.2010.07.003 and PMC identifier 3104503.
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Abstract
The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.