No bones about it: insulin modulates skeletal remodeling.
review · Level V
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- Record sourced from PubMed, PMID 20655463.
- Also identified by DOI 10.1016/j.cell.2010.07.001.
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Abstract
Advancing the hypothesis that bone remodeling is intimately linked to metabolic homeostasis, Fulzele et al. (2010) and Ferron et al. (2010) present evidence that insulin signaling promotes the activation of bone-forming osteoblasts and enhances production of osteocalcin, a secreted mediator of insulin sensitivity, through modulation of bone resorption.