Calcium and energy: making the cake and eating it too?
review · Level V
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- Record sourced from PubMed, PMID 20655464.
- Also identified by DOI 10.1016/j.cell.2010.07.007.
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Abstract
Mitochondrial calcium ions promote a number of events that sustain ATP levels in the cell. Cardenas et al. (2010) now demonstrate that the inositol 1,4,5-triphosphate receptor at the endoplasmic reticulum constitutively provides calcium for mitochondria. In the absence of this calcium transfer, cells use autophagy to sustain survival.