Cimetidine and ranitidine may not cross-react to cause thrombocytopenia.
case_report · Level V
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- Record sourced from PubMed, PMID 2066715.
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Abstract
We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia. The thrombocytopenia resolved spontaneously following discontinuation of cimetidine, and did not recur with ranitidine. We concluded that cimetidine and ranitidine do not necessarily cross-react to induce thrombocytopenia. Thus the exclusion of both H2-blockers in the event that one has caused thrombocytopenia may not be justified.
Medical subject headings
- Aged
- Cimetidine
- Cimetidine/adverse effects
- Cimetidine/therapeutic use
- Duodenal Ulcer
- Duodenal Ulcer/complications
- Duodenal Ulcer/drug therapy
- Humans
- Male
- Peptic Ulcer Hemorrhage
- Peptic Ulcer Hemorrhage/etiology
- Ranitidine
- Ranitidine/therapeutic use
- Thrombocytopenia
- Thrombocytopenia/chemically induced