Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug efficacy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20670948.
- Also identified by DOI 10.1158/1078-0432.CCR-10-1333 and PMC identifier 2913312.
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Abstract
A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics.
Medical subject headings
- Biomarkers, Tumor
- Biosensing Techniques
- Fluorescence Resonance Energy Transfer
- Neoplasms