Transfer of cholesterol by the NPC team.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20674853.
- Also identified by DOI 10.1016/j.cmet.2010.07.004.
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Abstract
The mechanisms of intracellular cholesterol transport are largely unknown. In this issue of Cell Metabolism, Wang et al. (2010) identify amino acid residues on the lumenal lysosomal protein Niemann-Pick C2 (NPC2) that are required for intralysosomal transfer of endocytosed cholesterol to membrane-bound NPC1 via a process that avoids movement of hydrophobic cholesterol through the aqueous phase.