Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20675585.
- Also identified by DOI 10.1073/pnas.1009412107 and PMC identifier 2930460.
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Abstract
Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.
Medical subject headings
- Cellular Reprogramming
- Monocytes
- Neurons
- Proto-Oncogene Proteins
- Stem Cells
- Trans-Activators