Mechanical regulation of cell function with geometrically modulated elastomeric substrates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20676108.
- Also identified by DOI 10.1038/nmeth.1487 and PMC identifier 3069358.
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Abstract
We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.
Medical subject headings
- Endothelial Cells
- Mesenchymal Stem Cells
- Polymers
- Stress, Mechanical