Glutamate joins the ranks of immunomodulators.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 20689547.
- Also identified by DOI 10.1038/nm0810-856 and PMC identifier 2997749.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Elevated amounts of glutamate, which acts as a neurotransmitter but is also a neurotoxin, are a hallmark of the autoimmune neurological disease multiple sclerosis and may contribute to its pathology. The discovery that a receptor for glutamate can inhibit the development of autoimmunity and protect from neuroinflammation in a mouse model of multiple sclerosis suggests that glutamate may also have a protective role and that its receptor may represent a therapeutic target (pages 897–902).
Medical subject headings
- Glutamic Acid
- Immunologic Factors