Stem cells and DNA damage: persist or perish?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20691895.
- Also identified by DOI 10.1016/j.cell.2010.07.030.
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Abstract
Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.