The pioneer round of translation: features and functions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20691898.
- Also identified by DOI 10.1016/j.cell.2010.07.022 and PMC identifier 2950652.
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Abstract
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
Medical subject headings
- Protein Biosynthesis
- RNA, Messenger