Association screening of common and rare genetic variants by penalized regression.
other · Level V
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- Record sourced from PubMed, PMID 20693321.
- Also identified by DOI 10.1093/bioinformatics/btq448 and PMC identifier 3025646.
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Abstract
This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants. The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes. Rare variant discovery by group penalized regression is now implemented in the free program Mendel at http://www.genetics.ucla.edu/software/.
Medical subject headings
- Breast Neoplasms
- Genome-Wide Association Study