Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model.
Level V
Where this comes from
- Record sourced from PubMed, PMID 20706214.
- Also identified by DOI 10.1038/ki.2010.199 and PMC identifier 3863579.
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Abstract
Diabetic nephropathy is a common, complex disease with a clear genetic predisposition. Human gene association studies are beginning to bear fruit by identifying gene loci that increase diabetic nephropathy risk. Chua et al. report a similar study in diabetic mice that reveals a major nephropathy locus on chromosome 8. Could this be a human nephropathy gene? Time will tell, but such findings will at least improve the use of mouse models of human kidney disease.
Medical subject headings
- Chromosome Mapping
- Diabetic Nephropathies
- Genetic Predisposition to Disease