Layer-by-layer assembly of β-estradiol loaded mesoporous silica nanoparticles on titanium substrates and its implication for bone homeostasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 20717987.
- Also identified by DOI 10.1002/adma.201000854.
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Abstract
Drug-loadingmesoporous silica nanoparticles that serve as a nanoreservoir-type drug-delivery system are successfully attached to titanium substrates via the layer-by-layer assembly technique (see scheme). The obtained structure demonstrates great potential for regulating the biological behaviors of osteoblasts/ steoclasts in order to maintain bone homeostasis. The approach we present here may have wide applications in implant technology, tissue engineering, and regenerative medicine.
Medical subject headings
- Calcification, Physiologic
- Estradiol
- Nanoparticles
- Silicon Dioxide