The ins and outs of EGFR asymmetry.
basic_science · Level V
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- Record sourced from PubMed, PMID 20723751.
- Also identified by DOI 10.1016/j.cell.2010.08.003.
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Abstract
The epidermal growth factor receptor (EGFR) regulates cell proliferation in many tissues. A new structure of the Drosophila EGFR presented by Alvarado et al. (2010) reveals an asymmetric dimer with the ligand bound to only one subunit. The structure provides a rationale for the receptor's negative cooperativity and necessitates a reconsideration of models for activation of human EGFR.