Up a hydrophobic creek with a short paddle.

Hulse, Raymond E; Li, Qufei; Perozo, Eduardo · Cell · 2010

basic_science · Level V

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Abstract

The mechanism by which voltage-dependent ion channels sense membrane potentials has been the most intensively studied and debated topic in modern ion channel research. In this issue, Xu et al. (2010) provide new insights into the minimal topological and physicochemical features required for voltage sensing.