The Immunoproteasome Cleans up after Inflammation.
basic_science · Level V
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- Record sourced from PubMed, PMID 20723753.
- Also identified by DOI 10.1016/j.cell.2010.08.002.
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Abstract
Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.