Cyclophosphamide for rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20727534.
- Also identified by DOI 10.1016/j.jpeds.2010.07.006 and PMC identifier 3976575.
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Abstract
Patients with rapid-onset obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor syndrome have poor long-term outcomes. We report a patient who was treated successfully with high-dose cyclophosphamide immunoablation. This experience offers a novel therapeutic approach and an indirect insight into the underlying pathogenesis of this syndrome.
Medical subject headings
- Autonomic Nervous System Diseases
- Cyclophosphamide
- Hypothalamic Diseases
- Obesity
- Obesity Hypoventilation Syndrome