Defining the risks of mesenchymal stromal cell therapy.

Prockop, Darwin J; Brenner, Malcolm; Fibbe, Willem E; Horwitz, Edwin; Le Blanc, Katarina; Phinney, Donald G; Simmons, Paul J; Sensebe, Luc et al. · Cytotherapy · 2010

basic_science · Level V

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Abstract

Abstract We address the issue of the potential for malignant transformation of cultured mesenchymal stromal cells (MSC) commonly used in clinical cell-therapy protocols and describe the culture conditions under which tumorigenesis is likely to be an extremely uncommon event.

Medical subject headings