Opioid-induced preconditioning is dependent on caveolin-3 expression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20736437.
- Also identified by DOI 10.1213/ANE.0b013e3181f3351a and PMC identifier 3098574.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We tested the hypothesis that caveolin-3 (Cav-3) is essential for opioid-induced preconditioning in vivo. Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a δ-selective opioid agonist, or naloxone, a nonselective opioid antagonist. Controls were protected from I/R injury by SNC. No protection was produced by SNC in Cav-3 knockout mice. Cav-3 overexpressing mice showed innate protection from I/R compared with controls that was abolished by naloxone. Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.
Medical subject headings
- Analgesics, Opioid
- Benzamides
- Caveolin 3
- Myocardial Infarction
- Myocardial Reperfusion Injury
- Myocardium
- Piperazines
- Receptors, Opioid, delta