Basic science of intra-articular fractures and posttraumatic osteoarthritis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20736796.
- Also identified by DOI 10.1097/BOT.0b013e3181ed298d and PMC identifier 3662545.
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Abstract
Intra-articular fractures represent the primary etiologic factor leading to posttraumatic osteoarthritis. The pathomechanisms linking intra-articular fractures to end-stage cartilage destruction are poorly understood. However, fracture-related chondrocyte death has been linked to posttraumatic osteoarthritis. Researchers have made significant progress in understanding the pathomechanical link between injury and chondrocyte death. This article reviews recent basic scientific progress investigating intraarticular fractures and fracture-related chondrocyte death and dysfunction.
Medical subject headings
- Age Factors
- Animals
- Apoptosis
- Cartilage, Articular
- Cartilage, Articular/injuries
- Cartilage, Articular/pathology
- Cattle
- Chondrocytes
- Chondrocytes/pathology
- Disease Models, Animal
- Fractures, Cartilage
- Fractures, Cartilage/complications
- Fractures, Cartilage/pathology
- Humans
- Intra-Articular Fractures
- Intra-Articular Fractures/complications
- Intra-Articular Fractures/pathology
- Osteoarthritis
- Osteoarthritis/etiology
- Osteoarthritis/pathology