Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20739008.
- Also identified by DOI 10.1016/j.ajog.2010.06.072.
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Abstract
Gestational trophoblastic neoplasia (GTN) includes invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The overall cure rate in treating these tumors is currently >90%. Thorough evaluation and staging allow selection of appropriate therapy that maximizes chances for cure while minimizing toxicity. Nonmetastatic (stage I) and low-risk metastatic (stages II and III, score <7) GTN can be treated with single-agent chemotherapy resulting in a survival rate approaching 100%. High-risk GTN (stages II-IV, score ≥7) requires initial multiagent chemotherapy with or without adjuvant radiation and surgery to achieve a survival rate of 80-90%.
Medical subject headings
- Gestational Trophoblastic Disease