Structural genomics of histone tail recognition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20739309.
- Also identified by DOI 10.1093/bioinformatics/btq491 and PMC identifier 2951094.
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Abstract
The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures of histone tails in complex with human proteins. Each article is composed of interactive 3D slides that dissect the structural mechanism underlying the recognition of specific sequences and histone marks. A concise text html-linked to interactive graphics guides the reader through the main features of the interaction. This resource can be used to analyze and compare binding modes across multiple histone recognition modules, to evaluate the chemical tractability of binding sites involved in epigenetic signaling and design small molecule inhibitors. http://www.thesgc.org/resources/histone_tails/ matthieu.schapira@utoronto.ca Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genomics
- Histones