CD14 : a candidate biomarker for the prognosis of polycystic kidney disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20805816.
- Also identified by DOI 10.1038/ki.2010.228 and PMC identifier 4437201.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Zhou et al. validate the expression of markers of the innate immune system in the cpk mouse model of polycystic kidney disease (PKD), in human recessive PKD, and in human autosomal dominant PKD and show that CD14 expression correlates with PKD progression, even from very early stages of disease. Moreover, they show that CD14 is expressed from the renal tubule epithelial cells, suggesting a mechanism of Toll-like receptor-4 activation in PKD prior to the infiltration of inflammatory cells.
Medical subject headings
- Lipopolysaccharide Receptors
- Polycystic Kidney Diseases