Torque-induced slip of the rotary motor F1-ATPase.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20809627.
- Also identified by DOI 10.1021/nl102414d.
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Abstract
F(1)-ATPase plays an essential role in cellular metabolism by linking rotational motion to ATP hydrolysis/synthesis. We measure the torque profile of F(1) in both ATP hydrolysis and synthesis directions using a novel magnetic nanorod assay. F(1) is found to decouple ATP synthesis from rotary motion at a surprisingly low torque. This low-torque slip mechanism protects the enzyme from excessive load and may play a broader biological role by reducing the production of reactive oxygen species.
Medical subject headings
- Adenosine Triphosphate
- Magnetics
- Nanotubes
- Proton-Translocating ATPases