Phosphotyrosine signaling: evolving a new cellular communication system.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20813250.
- Also identified by DOI 10.1016/j.cell.2010.08.023 and PMC identifier 2950826.
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Abstract
Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.
Medical subject headings
- Evolution, Molecular
- Phosphotyrosine
- Signal Transduction