Fishing out a sensor for anti-inflammatory oils.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20813253.
- Also identified by DOI 10.1016/j.cell.2010.08.022.
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Abstract
The omega-3 fatty acids have anti-inflammatory and antidiabetic effects in humans. Now, Oh et al. (2010) demonstrate that the G protein-coupled receptor GPR120 is a receptor for omega-3 fatty acids on macrophages and fat cells. Activation of GPR120 by omega-3 fatty acids inhibits multiple inflammation cascades in macrophages and reverses insulin resistance in obese mice.