A new spin on planar cell polarity.
basic_science · Level V
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- Record sourced from PubMed, PMID 20813254.
- Also identified by DOI 10.1016/j.cell.2010.08.025 and PMC identifier 2964088.
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Abstract
The generation of planar cell polarity (PCP) and tissue shape during morphogenesis is tightly linked, but it is not clear how. Aigouy et al. (2010) now show in the developing Drosophila wing that PCP initially has a radial orientation that becomes realigned to the proximal-distal axis of organ shape by mechanical forces and cell rearrangements mediated by Dachsous.