Viable rat-mouse chimeras: where do we go from here?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20813255.
- Also identified by DOI 10.1016/j.cell.2010.08.021.
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Abstract
In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.