KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.
review · Level V
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- Record sourced from PubMed, PMID 20814421.
- Also identified by DOI 10.1038/nrc2899 and PMC identifier 4085546.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt-β-catenin cascades. The creation of mouse models that closely resemble the human disease has provided a platform to better understand when and in which cell types these pathways are misregulated during PDAC development. Here we examine the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt-β-catenin signalling dictate the specification and oncogenic properties of PDAC.
Medical subject headings
- Carcinoma, Pancreatic Ductal
- Genes, ras
- Hedgehog Proteins
- Pancreatic Neoplasms
- Wnt Proteins